Gastrointestinal release behaviour of modified-release drug products: Dynamic dissolution testing of mesalazine formulations
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Gastrointestinal release behaviour of modified-release drug products: dynamic dissolution testing of mesalazine formulations.
The aminosalicylate mesalazine (mesalamine) forms the mainstay of treatment in ulcerative colitis (UC), a disease for which many commercial modified-release products have been developed with the aim of providing targeted gastrointestinal release. The release profiles of five of these commercial formulations were evaluated in bicarbonate buffer using a novel dissolution model that mimics the dyn...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2015
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2015.02.051